Figure 9. Loss of Cones in Rpe65^−/−/Bax^−/− Mice Was Confirmed by qPCR Analysis of Cone-specific Markers.

Strong decrease in transcriptional expression of (A) Gnat2, (B) Swl-opsin and (C) Mwl-opsin at 1 (1 m) and 2 months (2 m) of age in Rpe65^−/− and Rpe65^−/−/Bax^−/− retinas indicated that loss of cones was not rescued in the absence of pro-apoptotic Bax. Data are the mean±SE of four independent experiments. # p<0.001 by ANOVA test for Rpe65^−/− versus wt and Bax^−/−; * p<0.05 by ANOVA test for Rpe65^−/− versus wt; ** p<0.001 by ANOVA test for Rpe65^−/− versus Bax^−/−.