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Inhibitory pre- and postsynaptic neurons. AEDs can enhance GABAA effect by increasing the frequency or duration of the channel opening. Levetiracetam can displace Zn2+, which reduces Cl- currents, from the GABAA . Vigabatrin inhibits GABA-transaminase thereby increasing intracellular GABA. Tiagabine inhibits the uptake of GABA from the synaptic cleft which increases extracellular GABA.
