Table 2.
Adjusted mean systolic and diastolic blood pressure (BP) and systolic and diastolic BP decreases after the addition of trandolapril to verapamil sustained release monotherapy in different races/ethnicities according to AGTR1 1166 A→C genotype (n = 551)
Adjusted Systolic/Diastolic BP (mm Hg) | |||
---|---|---|---|
A/A | C Allele Carriers | p Value (systolic/diastolic BP) |
|
White | 139.9 ± 2.5/77.7 ± 1.4 | 141.0 ± 2.4/79.5 ± 1.4 | 0.63/0.12 |
Black | 143.9 ± 6.3/82.8 ± 3.3 | 137.1 ± 7.8/80.1 ± 4.1 | 0.22/0.36 |
Hispanic | 144.6 ± 2.7/85.3 ± 1.4 | 141.3 ± 3.0/83.9 ± 1.2 | 0.11/0.19 |
Systolic/Diastolic BP Decrease (mm Hg) | |||
A/A | C Allele Carriers | p Values (systolic/diastolic BP decrease) |
|
White | −8.5 ± 2.5/−5.6 ± 1.4 | −7.4 ± 2.4/−3.7 ± 1.4 | 0.63/0.16 |
Black | −7.0 ± 6.3/−3.1 ± 3.4 | −13.9 ± 7.8/−6.3 ± 4.2 | 0.22/0.29 |
Hispanic | −3.3 ± 2.7/−0.5 ± 1.4 | −6.6 ± 3.0/−1.9 ± 1.5 | 0.11/0.12 |
C Allele carriers were combined in 1 group. p Values were adjusted for multiple comparisons. Results presented as mean ± SE.