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. Author manuscript; available in PMC: 2009 Aug 4.
Published in final edited form as: FEBS Lett. 2007 Aug 14;581(23):4403–4410. doi: 10.1016/j.febslet.2007.08.008

Figure 4.

Figure 4

Caspase-3-cleavage is required for GRASP-1-mediated JNK pathway activation. (A–B) Full length GRASP-1 containing a mutated Caspase-3 cleavage site (F.L.-D/E) is a much less effective activator for JNK signaling. (A) Western blot and quantification show comparable expression levels of Myc-GRASP1-F.L.-D/E and Myc-GRASP1-C. n.s: not significant. N=3. (B) GRASP1-C but not GRASP1-F.L.-D/E enhances JNK phosphorylation. *: p<0.05 (t-test), n=3. (C) A model that summarizes our findings that GRASP-1 serves as a scaffold protein for JNK signaling pathway.