LPS-stimulated production of interleukin-6 increases over time in subjects with chronic interpersonal stress. For the purpose of illustration, the sample was stratified at the median of chronic interpersonal stress (2.4 on a 1–5 scale), and the groups’ IL-6 values were compared using a repeated-measures ANOVA. Covariates included age, ethnicity, oral contraceptives, socioeconomic status, central adiposity, and physical activity. The analysis yielded a significant Stress X Time interaction, F (1,95) = 4.11, p = .05, indicating that the low and high stress groups changed differentially over the 6-month follow-up. Data are plotted as mean + standard error.