Table 2.

Effects of various doses of ethanol on plasma kynurenine(s) concentrations

	Dose of ethanol (g/kg body weight)
Parameter	0	0.2	0.4	0.6	0.8
[Trp]	38 ± 3	28 ± 3*	22 ± 1*	20 ± 1*	18 ± 1*
[Kyn]	0.65 ± 0.10	1.17 ± 0.11*	1.09 ± 0.11*	1.13 ± 0.13*	1.16 ± 0.11*
TP (%)	1.72 ± 0.35	4.17 ± 0.50*	4.96 ± 0.35*	5.64 ± 0.75*	6.44 ± 0.12*
[Kyns]	4.57 ± 0.62	4.27 ± 0.80	4.10 ± 0.55	4.30 ± 0.72	5.67 ± 0.72
TTOx (%)	12.0 ± 1.8	15.2 ± 2.5	18.6 ± 2.7	21.5 ± 4.5	31.5 ± 4.3*

Values (in μM or as%) are means ± SEM for n = 10 per group.

^*P = 0.0229 at least (one-way ANOVA with replicated measures).

Trp, tryptophan; Kyn, kynurenine; Kyns, kynurenines; TP, Trp pyrrolase, expressed as the % [Kyn]/[Trp]; TTOx, total Trp oxidation, expressed as the % [Kyns]/[Trp].