Table 1.

Genes involved in hepatic xenobiotic metabolism and excretion that were significantly altered in expression by dietary α-tocopherol supplementation (P < 0.05).

Gene name	Gene ID	GenBank	Expression Intensity 1 (35 IU)	Expression Intensity 1 (1000 IU)	Fold-change2	Direction
Sulfotransferase 2a	Sult2a	NM_009286	11.40 ± 0.54	14.84 ± 0.59	10.8	up
ABC, sub-family B, member 1a	Mdr1a†	M30697	6.77 ± 0.15	7.70 ± 0.28	1.9	up
Glutathione S-transferase, mu 3	Gstm3	J03953	7.00 ± 0.13	7.93 ± 0.26	1.9	up
Constitutive Androstane receptor	Car	AS009328	11.69 ± 0.15	12.58 ± 0.19	1.8	up
Pregnane X receptor	Pxr	AF031814	9.09 ± 9.09	9.74 ± 0.05	1.6	up
P450 oxidoreductase	Por	NM_008898	12.49 ± 0.10	13.15 ± 0.07	1.5	up
Cytochrome P450 3a11	Cyp3a11	BC010528	13.97 ± 0.13	14.37 ± 0.02	1.3	up
Squalene epoxidase	Sqle	NM_009270	10.59 ± 0.08	9.16 ± 0.02	2.7	down
Cytochrome P450 7b1	Cyp7b1	NM_007825	11.56 ± 0.13	10.53 ± 0.22	2.2	down

Mice were fed a diet containing either 35 IU or 1000 IU all-rac-α-tocopherol/kg diet, hepatic RNA was prepared and gene expression was determined by microarray analysis using the Mouse 430 2.0 GeneChip and GeneSifter Software as described in Methods.

^†Mdr1a is also referred to as Abcb1a.

¹Expression intensities are expressed as mean ± SE of log₂ transformed data (arbitrary units), n = 3 / dietary treatment.

²Fold-change in expression intensity is expressed for 1000 IU group relative to 35 IU group.