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. 2008 Nov 19;100(22):1630–1642. doi: 10.1093/jnci/djn378

Figure 5.

Figure 5

Serum levels of interleukin 6 (IL-6), interleukin 8 (IL-8), and vascular endothelial growth factor (VEGF) from mice intraperitoneally injected with SKOV-3 cells expressing lysophosphatidic acid (LPA) receptors. Female nude mice were injected intraperitoneally with the lentivirus-transduced SKOV-3 cells (10 × 106 per mouse) that express LPA1, LPA2, or LPA3 receptors. Three weeks later, blood was collected from the tail vein to determine concentrations of IL-6 (A), IL-8 (B), and VEGF (C) in serum. Each data point corresponds to IL-8 or IL-6 in individual mouse serum (LacZ [n = 23], LPA1 [n = 22], LPA2 [n = 23], or LPA3 [n = 24]) or VEGF in mouse serum (LacZ [n = 10], LPA1 [n = 9], LPA2 [n = 10], or LPA3 [n = 10]). Data points represent concentrations determined by enzyme-linked immunosorbent assay. P values are derived from comparisons with LacZ controls using Student t test, and horizontal lines represent the mean of values.