Table 5.
Relationship of BioZ parameters with clinical outcomes.
| Hazard Ratio (95% CL) | |||
|---|---|---|---|
| Baseline BioZ variable | ESCAPE Primary Endpoint | Time to Death | Time to Death/Rehospitalization |
| CO | 0.95 (0.86,1.07) | 0.76 (0.56, 1.03) | 0.94 (0.82, 1.09) |
| LCWI | 1.01 (0.97, 1.06) | 0.54 (0.30, 0.98) | 1.04 (1.00, 1.09) |
| LVET | 1.00 (0.63, 1.58) | 2.71 (0.86, 8.56) | 1.04 (0.58, 1.84) |
| STR | 0.86 (0.36, 2.08) | 0.33 (0.32, 3.32) | 1.18 (0.38, 3.65) |
| SV | 0.99 (0.99, 1.00) | 0.99 (0.97, 1.01) | 1.00 (0.99, 1.01) |
| SVR | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) |
| TFC | 1.01 (0.99, 1.02) | 1.01 (0.97, 1.04) | 1.00 (0.98, 1.02) |
| VI | 0.99 (0.98, 1.00) | 0.99 (0.97, 1.02) | 0.98 (0.97, 1.00) |
| AI | 1.00 (0.99, 1.01) | 1.00 (0.99, 1.02) | 0.99 (0.98, 1.00) |
| TFCI | 1.01 (0.99, 1.03) | 1.02 (0.97, 1.07) | 0.99 (0.96, 1.02) |
| ICG score | 1.04 (0.97, 1.11) | 1.02 (0.85, 1.22) | 1.03 (0.95, 1.13) |
| Discharge BioZ Variable | Time to Death | Time to Death/Rehospitalization | |
| CO | 0.73 (0.51, 1.06) | 0.97 (0.85, 1.11) | |
| LCWI | 0.48 (0.21, 1.07) | 0.98 (0.92, 1.04) | |
| STR | 2.2 (0.21, 23.49) | 2.5 (0.83, 7.69) | |
| SV | 0.98 (0.96, 1.01) | 1.00 (0.99, 1.01) | |
| SVR | 1.02 (1.00, 1.03) | 1.00 (0.99, 1.02) | |
| TFC | 1.02 (0.96, 1.08) | 1.00 (0.97, 1.03) | |
| VI | 0.99 (0.96, 1.03) | 0.99 (0.97, 1.01) | |
| AI | 1.01 (0.99, 1.02) | 1.00 (0.99, 1.01) | |
| TFCI | 1.05 (0.96, 1.16) | 0.99 (0.95,1.03) | |
| ICG score | 1.07 (0.84, 1.37) | 1.04 (0.93, 1.16) | |
Abbreviations: AC=acceleration index; CO=cardiac output; ICG=impedance cardiography; LCWI=left cardiac work index; LVET=left ventricular ejection time; STR=systolic time ratio; SV=stroke volume; SVR=systemic vascular resistance; TFC=thoracic fluid content; TFCI=thoracic fluid content index; VI=velocity index.
The number of subjects who contributed observations for the various parameters is 157 at baseline and 123 at discharge.