Skip to main content
. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: J Immunol. 2009 Apr 15;182(8):4899–4909. doi: 10.4049/jimmunol.0803242

Figure 8. IFN-γ is Required For iFt Plus CTB-Induced Protection.

Figure 8

C57BL/6 (A) and IFN-γ-deficient (B) mice were divided into three groups, immunized and infected with F. tularensis LVS as described in Figure 1. Survival was monitored for at least 21 days post-infection. IFN-γ-deficient mice were not protected against F. tularensis LVS challenge when immunized with iFt plus CTB (B). Sera from IFN-γ-deficient mice were obtained prior to the F. tularensis LVS challenge and the F. tularensis-specific IgA levels were measured by ELISA. The mice immunized with iFt plus CTB exhibited a three-fold increase in IgA levels versus iFt-immunized mice (C). These data are representative of two separate experiments.