FIGURE 2.
HCM activates human monocytes and induces IL-8 from (A) PBMCs (p<0.001); (B) monocytes (p<0.001); and (C) human monocytic THP-1 cells (p<0.001); treated with HCM, S2–16 HCM peptide, or SKM for 24h. Supernatants assayed for IL-8. (D) HCM peptides S2–16 and S2–28 stimulated IL-8 secretion from human monocytes. Values are means ± s.e.m. NS, not significant. P value obtained by Tukey’s test using one way ANOVA.