TABLE 1.
Adverse events associated with clinical islet transplantation*
| Immunosuppressive-related (%) | Procedure-related (%) |
|---|---|
| Oral ulcers (96) | Elevated liver enzymes (54) |
| Anemia (60) | Abdominal pain (50) |
| Diarrhea (50) | Nausea/vomiting (50) |
| Weight loss (50) | Fatty liver (long term) (20) |
| Fatigue (50) | Peritoneal hemorrhage (15) |
| LDL elevation (50) | Portal vein thrombosis (4) |
| Hypertension (50) | Gall bladder puncture (3) |
| Decline in GFR (50) | |
| Proteinuria (50) | |
| Peripheral edema (30) | |
| Acne (10) | |
| Neutropenia (<10) | |
| Tremor (<10) | |
| Miscellaneous – arthralgia, pneumonitis, hematuria, infection, PTLD (rare) |
*
Approximate per cent incidence. GFR Glomerular filtration rate; LDL Low density lipoprotein cholesterol; PTLD Post-transplant lymphoproliferative disorder