Fig. 1.

Selected examples of nuclear positioning are shown. Nuclei are light blue, differentiated nuclei are dark blue, microtubule organizing centers (MTOCs) are red, and microtubules are green. Arrows represent development over time. (A) In budding yeast, the nucleus must be positioned to the bud neck prior to mitosis. (B) In sporulating filamentous fungi, nuclei are evenly spaced in the syncytia. (C) In a newly fertilized C. elegans embryo, the male (right) and female (left) pronuclei must migrate towards one another before the first mitotic event. (D) In the developing vertebrate neuroepithelium, nuclei migrate basally and then apically, to where they divide. Differentiated cells often leave the pseudostratified epithelium, which requires additional nuclear migration events. (E) In a mammalian skeletal muscle, nuclei are spaced out evenly, except for specialized nuclei at the neuromuscular junction (innervating neuron is yellow).