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editorial
. 2009 Feb 18;122(5):577–586. doi: 10.1242/jcs.037622

Fig. 3.

Fig. 3.

The nuclear-envelope bridge, and roles of KASH proteins connecting the ONM to the cytoskeleton. SUN proteins (yellow and red) dimerize at the INM and recruit KASH proteins (different shades of blue) to the ONM. The central link of the bridge occurs in the perinuclear space, where the KASH domain (purple) of KASH proteins directly interacts with two domains in the SUN protein, the SUN domain (red) and a less-conserved domain (yellow). The large cytoplasmic domains of KASH proteins (shades of blue) then extend away from the ONM into the cytoplasm to interact with the cytoskeleton. (A) One class of KASH proteins (including ANC-1, Syne-1 and Syne-2) connect the ONM to actin filaments (tan) to anchor nuclei. (B) Klarsicht and ZYG-12 connect the ONM to centrosomes (green). Both function through dynein (white). ZYG-12 in the ONM dimerizes with KASH-less ZYG-12 in the centrosome. (C) UNC-83 and UNC-84 mediate nuclear migration in a centrosome-independent mechanism that remains unknown. (D) Nesprin-3 links the ONM to intermediate filaments (gray) through plectin. See text for more details.