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. 2009 Jul 23;6:113. doi: 10.1186/1743-422X-6-113

Table 1.

Nucleotide and amino acid substitutions in the informative sites of genotype I.

Nucleotide Protein Domains


Genotype I

Position Lineage Lineage II Position Lineagen Type of amino acid Changes
Sub-Lineage


Gene Codon I II I II Protein I II I



48 3 G A
135 3 T C


174 3 G A II
202 1 A G 68 I V Conservative
219 3 A G
222 3 T C
282 3 T C
342 3 G A
366 3 A G
393 3 A G


441 3 T C I
474 3 T C
506 2 C T 169 A V Conservative
516 3 T C
537 3 C T


588 3 A G II
633 3 C T
640 1 T C
645 3 C T
663 3 A G
684 3 T C
692 2 G A 231 R K Conservative
714 3 T C
735 3 G A
759 3 A G
777 3 T C


849 3 T C I


909 1 A G 303 T A Nonconservative III
912 3 C T
1101 3 T A
1153 1 C T
1172 2 G A 391 R K Conservative


1269 3 G A TM
1281 3 G A
1302 3 C G
1317 3 G A
1329 3 A G
1380 3 C T
1436 2 C T 479 A V Conservative
1466 2 T C 489 V A Conservative

Domain I: 1–156nt (1–52aa); 397–573nt (133–191aa); 835–882nt (279–294aa)

Domain II: 157–396nt (53–132aa); 574–834nt (192–278aa)

Domain III: 883–1176nt (295–392aa)

Domain TM: 1177–1479nt (393–493aa)

nt:are indicated the nucleotide positions

aa::are indicated the amino acid positions