Table 2.
Primary and Secondary Outcome Measures with Prophylaxis versus Placebo
Outcome Measure | RR all Antibody Prophyaxis | RR Palivizumab | RR RSV-IGIV |
---|---|---|---|
RSV Hospitalization | 0.53 (0.43, 0.66), P < 0.00001 | 0.50 (0.38, 0.66); 3 14,15,16 studies, 1663 treated, P < 0.00001 | 0.59 (0.42, 0.83); 3 11,12,13 studies, 533 treated, P = 0.002 |
ICU Admission | 0.39 (0.21, 0.70), P = 0.002 | 0.29 (0.14, 0.59); 2 15,16 studies, 1641 treated, P = 0.0007 | 0.50 (0.24, 1.04); 311,12,13 studies, 533 treated, P = 0.06 |
Mechanical Ventilation | 0.76 (0.43, 1.36), P = 0.36 | 1.10 (0.20, 6.09); 215,16 studies, 1641 treated, P = 0.91 | 0.77 (0.33, 1.79); 311,12,13 studies, 533 treated, P = 0.55 |
RSV Infection | 0.78 (0.60, 1.01), P = 0.06 | 0.45 (0.09, 2.22); 114 study, 22 treated, P = 0.33 | 0.79 (0.61, 1.03); 211,13 studies, 283 treated, P = 0.08 |
All Cause Mortality | 0.95 (0.55, 1.65), P = 0.86 | 0.71 (0.42, 1.19); 215,16 studies, 1641 treated, P = 0.19 | 1.53 (0.65, 3.61); 311,12,13 studies, 533 treated, P = 0.33 |