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. 2009 Aug 5;101(15):1066–1082. doi: 10.1093/jnci/djp180

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© 2009 The Author(s).

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Summary odds ratios (ORs; in case–control studies) or relative risks (RRs; in cohort studies) of hepatocellular carcinoma (HCC) for PreS (A), C1653T (B), T1753V (C), A1762T/G1764A (D), C1858T (E), and G1896A (F) mutations. Squares represent study-specific estimates (size of the square reflects the study-specific statistical weight); horizontal lines represent 95% confidence intervals (CIs); diamonds represent summary estimates with corresponding 95% CIs. Test for heterogeneity: (A) P = .045, I² = 49.3%; (B) P = .197, I² = 25.9%; (C) P < .001, I² = 66.3%; (D) P < .001, I² = 76.4%; (E) P < .001, I² = 83.2%; (F) P < .001, I² = 80.0%. A random-effects model was used for all analyses. All statistical tests were two-sided. NCC = nested case–control; PCC = prevalence case–control; ICC = incidence case–control.

Summary odds ratios (ORs; in case–control studies) or relative risks (RRs; in cohort studies) of hepatocellular carcinoma (HCC) for PreS (A), C1653T (B), T1753V (C), A1762T/G1764A (D), C1858T (E), and G1896A (F) mutations. Squares represent study-specific estimates (size of the square reflects the study-specific statistical weight); horizontal lines represent 95% confidence intervals (CIs); diamonds represent summary estimates with corresponding 95% CIs. Test for heterogeneity: (A) P = .045, I² = 49.3%; (B) P = .197, I² = 25.9%; (C) P < .001, I² = 66.3%; (D) P < .001, I² = 76.4%; (E) P < .001, I² = 83.2%; (F) P < .001, I² = 80.0%. A random-effects model was used for all analyses. All statistical tests were two-sided. NCC = nested case–control; PCC = prevalence case–control; ICC = incidence case–control.