Table 11.
Genes involved in Proteolysis
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| CTSL | 37391_at | 1.43 | 0.05 | cathepsin L | proteolysis and peptidolysis | cathepsin L activity / hydrolase activity | extracellular / lysosome | --- |
| KLK8 | 37131_at | 1.11 | 0.02 | kallikrein 8 (neuropsin/ovasin) | neurogenesis / proteolysis and peptidolysis | chymotrypsin activity / hydrolase activity / peptidase activity / trypsin activity | --- | --- |
| YME1L1 | 40988_at | 0.91 | 0.03 | YME1-like 1 (S. cerevisiae) | proteolysis and peptidolysis | ATP binding / hydrolase activity / metalloendopeptidase activity / nucleotide binding | membrane / mitochondrion | --- |
| CPZ | 37248_at | 0.91 | 0.05 | carboxypeptidase Z | development / proteolysis and peptidolysis | carboxypeptidase A activity / carboxypeptidase activity / transmembrane receptor activity | membrane | --- |
| LAMP2 | 38403_at | 0.83 | 0.03 | lysosomal-associated membrane protein 2 | --- | --- | integral to plasma membrane / lysosomal membrane | --- |
| ADAM9 | 34761_r_at | 0.83 | 0.01 | a disintegrin and metalloproteinase domain 9 (meltrin gamma) | protein kinase cascade / proteolysis and peptidolysis | SH3 domain binding / hydrolase activity / integrin binding / metalloendopeptidase activity / protein binding / protein kinase binding / zinc ion binding | integral to plasma membrane | --- |
| CTSB | 32372_at | 0.67 | 0.04 | cathepsin B | proteolysis and peptidolysis | cathepsin B activity / hydrolase activity | intracellular / lysosome | --- |
| SPUVE | 40078_at | 0.67 | 0.01 | protease, serine, 23 | proteolysis and peptidolysis | chymotrypsin activity / hydrolase activity / trypsin activity | --- | --- |