Table 12.
Genes involved in G protein activity
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| RGS19 | 34268_at | 1.11 | 0.04 | regulator of G-protein signalling 19 | G-protein coupled receptor protein signaling pathway / autophagy / signal transduction / small GTPase mediated signal transduction | GTPase activator activity / protein binding / signal transducer activity | Golgi apparatus / heterotrimeric G-protein complex / membrane / membrane fraction | --- |
| GNA11 | 40562_at | 1.11 | 0.01 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) / guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | G-protein coupled receptor protein signaling pathway / protein amino acid ADP-ribosylation / signal transduction | GTP binding / GTPase activity / signal transducer activity | cytoplasm / plasma membrane | G_Protein_ Signaling |
| MC5R | 1141_at | 0.91 | 0.04 | melanocortin 5 receptor | G-protein signaling, coupled to cyclic nucleotide second messenger | melanocortin receptor activity / rhodopsin-like receptor activity | integral to plasma membrane | GPCRs_Class_ A_Rhodopsin-like / Peptide_GPCRs |
| RGS7 | 40653_at | 0.91 | 0.02 | regulator of G-protein signalling 7 | intracellular signaling cascade / regulation of G-protein coupled receptor protein signaling pathway | regulator of G-protein signaling activity / signal transducer activity | heterotrimeric G-protein complex | --- |
| FZD6 | 34472_at | 0.83 | 0.05 | frizzled homolog 6 (Drosophila) | G-protein coupled receptor protein signaling pathway / development / establishment of tissue polarity / frizzled signaling pathway | G-protein coupled receptor activity / Wnt receptor activity | integral to plasma membrane | Wnt_signaling |
| ADRB2 | 610_at | 0.83 | 0.02 | adrenergic, beta-2-, receptor, surface | G-protein coupled receptor protein signaling pathway / G-protein signaling, coupled to cAMP nucleotide second messenger / activation of MAPK / adenylate cyclase activation / endosome to lysosome transport / protein kinase cascade / receptor mediated endocytosis / transmembrane receptor protein tyrosine kinase activation (dimerization) | beta2-adrenergic receptor activity / rhodopsin-like receptor activity | endosome / integral to plasma membrane / lysosome | GPCRs_Class_ A_Rhodopsin-like / Monoamine_GP CRs |