Table 21.
Genes involved in Adhesion and Cell Motility
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| MAP2 | 1972_s_at | 1.43 | 0.02 | microtubule-associated protein 2 | microtubule stabilization | calmodulin binding / structural molecule activity | cytoskeleton / microtubule associated complex | MAPK_Cascade |
| DNAL4 | 33292_at | 1.25 | 0.02 | dynein, axonemal, light polypeptide 4 | microtubule-based movement | ATPase activity, coupled / microtubule motor activity | axonemal dynein complex | --- |
| FEZ1 | 37743_at | 1.25 | 0.03 | fasciculation and elongation protein zeta 1 (zygin I) | axon guidance / cell adhesion / neurogenesis | --- | --- | --- |
| EPB49 | 37192_at | 1.11 | 0.01 | erythrocyte membrane protein band 4.9 (dematin) | actin filament bundle formation / cytoskeleton organization and biogenesis | actin binding | actin cytoskeleton | --- |
| KRTHA1 | 36310_at | 1.11 | 0.03 | keratin, hair, acidic, 1 | epidermis development | structural constituent of cytoskeleton / structural molecule activity | intermediate filament | --- |
| SNTA1 | 35627_at | 1.11 | 0.03 | syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) | muscle contraction | actin binding / calcium ion binding / calmodulin binding | cytoskeleton / membrane | --- |
| SYNJ2 | 36532_at | 1.11 | 0.04 | synaptojanin 2 | --- | inositol or phosphatidylinosito l phosphatase activity | --- | --- |
| ITGB3 | 852_at | 1.11 | 0.05 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | blood coagulation / cell-matrix adhesion / integrin-mediated signaling pathway | protein binding / receptor activity | integrin complex | Integrin-mediated_cell_a dhesion |
| KIF1C | 35941_f_a t | 1.11 | 0.05 | kinesin family member 1C | retrograde transport, Golgi to ER | ATP binding / motor activity | Golgi apparatus / cytoskeleton / endoplasmic reticulum / microtubule associated complex | --- |
| THBS1 | 115_at | 0.91 | 0.02 | thrombospondin 1 | blood coagulation / cell adhesion / cell motility / development / neurogenesis | calcium ion binding / endopeptidase inhibitor activity / heparin binding / protein binding / signal transducer activity / structural molecule activity | extracellular | Inflammatory_R esponse_Pathwa y / TGF_Beta Sign_aling Pathway |
| TNPO1 | 33349_at | 0.91 | 0.02 | transportin 1 | cell adhesion / protein amino acid dephosphorylation | hydrolase activity / protein binding / protein tyrosine phosphatase activity / receptor activity / transmembrane receptor protein tyrosine phosphatase activity | integral to plasma membrane | --- |
| ADAM1 2 | 38769_at | 0.91 | 0.05 | a disintegrin and metalloproteinase domain 12 (meltrin alpha) | cell adhesion / myoblast fusion / proteolysis and peptidolysis | hydrolase activity / metalloendopeptida se activity / protein binding / zinc ion binding | integral to membrane / plasma membrane | --- |
| CD164 | 34819_at | 0.83 | 0.02 | CD164 antigen, sialomucin | cell adhesion / development / hemopoiesis / immune response / negative regulation of cell adhesion / negative regulation of cell proliferation / signal transduction | --- | endosome / integral to plasma membrane / membrane fraction / soluble fraction | --- |
| TSPAN-1 | 34775_at | 0.83 | 0.02 | tetraspan 1 | cell adhesion / cell motility / cell proliferation | --- | integral to membrane | --- |
| MAP7 | 39732_at | 0.83 | 0.03 | microtubule-associated protein 7 | establishment and/or maintenance of cell polarity / microtubule cytoskeleton organization and biogenesis | structural molecule activity | microtubule associated complex | --- |
| CD44 | 2036_s_at | 0.83 | 0.04 | CD44 antigen (homing function and Indian blood group system) | cell adhesion / cell-cell adhesion / cell-matrix adhesion | collagen binding / hyaluronic acid binding / receptor activity | integral to plasma membrane / membrane | --- |
| PAFAH1B1 | 32569_at | 0.83 | 0.04 | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | cell motility / cytokinesis / lipid metabolism / mitosis / neurogenesis / signal transduction | --- | cytoskeleton | Wnt_signaling / Glycerolipid metabolism |
| AMOTL2 | 38842_at | 0.77 | 0.0005 | angiomotin like 2 | --- | --- | --- | --- |
| ITGA1 | 37484_at | 0.77 | 0.02 | integrin, alpha 1 | cell-matrix adhesion / integrin-mediated signaling pathway | collagen binding / magnesium ion binding / receptor activity | integral to membrane / integrin complex | --- |
| ITGA1 | 120_at | 0.71 | 0.01 | integrin, alpha 1 | cell-matrix adhesion / integrin-mediated signaling pathway | collagen binding / magnesium ion binding / receptor activity | integral to membrane / integrin complex | --- |
| LAP1B | 40832_s_at | 0.71 | 0.01 | lamina-associated polypeptide 1B | --- | --- | --- | --- |
| SPARC | 671_at | 0.71 | 0.02 | secreted protein, acidic, cysteine-rich (osteonectin) | ossification | calcium ion binding / collagen binding | basement membrane | --- |
| PLS3 | 34794_r_at | 0.71 | 0.04 | plastin 3 (T isoform) | --- | actin binding / calcium ion binding | actin cytoskeleton | --- |
| PPP1R12A | 40438_at | 0.67 | 0.01 | protein phosphatase 1, regulatory (inhibitor) subunit 12A | regulation of muscle contraction | signal transducer activity | actin cytoskeleton | --- |
| CALD1 | 41739_s_at | 0.63 | 0.02 | caldesmon 1 | muscle contraction / muscle development | actin binding / calmodulin binding / myosin binding / tropomyosin binding | cytoskeleton | --- |
| KIF14 | 34563_at | 0.59 | 0.05 | kinesin family member 14 | --- | --- | --- | --- |
| CALD1 | 41738_at | 0.53 | 0.03 | caldesmon 1 | muscle contraction / muscle development | actin binding / calmodulin binding / myosin binding / tropomyosin binding | cytoskeleton | --- |