Table 4.
Genes with Antioxidant/ Xenobiotic Metabolism Function
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| GPX2 | 35194_at | 3.33 | 0.01 | glutathione peroxidase 2 (gastrointestinal) | response to oxidative stress | electron transporter activity / glutathione peroxidase activity / oxidoreductase activity | cytoplasm | Glutathione metabolism |
| GCLC | 31850_at | 2.50 | 0.02 | glutamate-cysteine ligase, catalytic subunit | circulation / cysteine metabolism / glutamate metabolism / glutathione biosynthesis | glutamate-cysteine ligase activity / ligase activity / nucleic acid binding | --- | Glutamate metabolism / Glutathione metabolism |
| EPHX1 | 38790_at | 2.00 | 0.00001 | epoxide hydrolase 1, microsomal (xenobiotic) | aromatic compound catabolism / response to toxin / xenobiotic metabolism | epoxide hydrolase activity / hydrolase activity | endoplasmic reticulum / integral to membrane / microsome | Tetrachloroethene degradation |
| UGT1A10 | 32392_s_at | 2.00 | 0.05 | UDP glycosyltransferas e 1 family, polypeptide A10 | metabolism / metabolism / xenobiotic metabolism / bilirubin conjugation / digestion / estrogen metabolism / xenobiotic metabolism | glucuronosyltransferase activity / transferase activity, transferring hexosyl groups / transferase activity / UDP-glycosyltransferase activity | integral to membrane / microsome / microsome / endoplasmic reticulum | Pentose and glucuronate interconversions / Androgen and estrogen metabolism / Starch and sucrose metabolism / Porphyrin and chlorophyll metabolism |
| ALDH3A2 | 40409_at | 1.67 | 0.01 | aldehyde dehydrogenase 3 family, member A2 | central nervous system development / epidermis development / lipid metabolism / peripheral nervous system development | aldehyde dehydrogenase (NAD) activity / oxidoreductase activity | endoplasmic reticulum / integral to membrane / microsome | Glycolysis / Gluconeogenesis / Ascorbate and aldarate metabolism / Fatty acid metabolism / Bile acid biosynthesis / Valine, leucine and isoleucine degradation / Lysine degradation / Arginine and proline metabolism / Histidine metabolism / Tryptophan metabolism / beta-Alanine metabolism / Glycerolipid metabolism / Pyruvate metabolism / 1,2-Dichloroethane degradation / Propanoate metabolism / Butanoate metabolism / Limonene and pinene degradation |
| GPX4 | 33931_at | 1.43 | 0.03 | glutathione peroxidase 4 (phospholipid hydroperoxidase) | development / phospholipid metabolism / response to oxidative stress | electron transporter activity / glutathione peroxidase activity / oxidoreductase activity / phospholipid-hydroperoxide glutathione peroxidase activity | mitochondrion | Glutathione metabolism |
| CBR1 | 38773_at | 1.43 | 0.04 | carbonyl reductase 1 | metabolism | 15-hydroxyprostaglandin dehydrogenase (NADP+) activity / carbonyl reductase (NADPH) activity / oxidoreductase activity / prostaglandin- E2 9-reductase activity | cytosol | Prostaglandin and leukotriene metabolism / Prostaglandin and leukotriene metabolism |
| MPST | 36124_at | 1.11 | 0.01 | mercaptopyruvate sulfurtransferase | cyanate catabolism / response to toxin / sulfate transport | 3-mercaptopyruvate sulfurtransferase activity / thiosulfate sulfurtransferase activity / transferase activity | mitochondrial matrix | Cysteine metabolism |
| GSTM1 | 556_s_at | 1.11 | 0.04 | glutathione S-transferase M1 | metabolism | glutathione transferase activity / transferase activity | cytoplasm | Glutathione metabolism |
| GSTZ1 | 1212_at | 0.91 | 0.04 | glutathione transferase zeta 1 (maleylacetoacet ate isomerase) | L-phenylalanine catabolism / aromatic amino acid family metabolism / tyrosine catabolism | catalytic activity / glutathione peroxidase activity / glutathione transferase activity / isomerase activity / maleylacetoacetate isomerase activity / transferase activity | cytoplasm / mitochondrion | Tyrosine metabolism / Styrene degradation / Glutathione metabolism |
| SMS | 38792_at | 0.91 | 0.05 | spermine synthase | methionine metabolism / polyamine metabolism | spermidine synthase activity / spermine synthase activity / transferase activity | --- | Urea cycle and metabolism of amino groups / Arginine and proline metabolism / beta-Alanine metabolism |
| PRNP | 36159_s_at | 0.83 | 0.00 | prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | metabolism | --- | --- | --- |
| MUT | 40105_at | 0.83 | 0.03 | methylmalonyl Coenzyme A mutase | metabolism | cobalt ion binding / isomerase activity / methylmalonyl-CoA mutase activity | mitochondrion | Valine, leucine and isoleucine degradation / Propanoate metabolism |
| DECR1 | 38104_at | 0.77 | 0.00 | 2,4-dienoyl CoA reductase 1, mitochondrial | metabolism | 2,4-dienoyl-CoA reductase (NADPH) activity / oxidoreductase activity | mitochondrion | --- |
| PON2 | 40504_at | 0.77 | 0.02 | paraoxonase 2 | --- | aryldialkylphosphatase activity / arylesterase activity / hydrolase activity | extracellular / membrane | --- |
| P4HA1 | 37037_at | 0.77 | 0.04 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | --- | oxidoreductase activity / oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen / procollagen-proline 4-dioxygenase activity | endoplasmic reticulum | Arginine and proline metabolism |
| GGH | 37263_at | 0.77 | 0.03 | gamma-glutamyl hydrolase (conjugase, folylpolygamma glutamyl hydrolase) | --- | exopeptidase activity / gamma-glutamyl hydrolase activity / hydrolase activity | lysosome | Folate biosynthesis |