Table 5.
Genes Involved in Electron, Ion, or Protein Transport
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| AKR1C1 | 32805_at | 5.00 | 0.002 | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) | canalicular bile acid transport / digestion / lipid metabolism / transport / xenobiotic metabolism | bile acid transporter activity / binding / electron transporter activity / oxidoreductase activity / trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity / aldo-keto reductase activity / electron transporter activity | cytoplasm | --- |
| NQO1 | 38066_at | 5.00 | 0.003 | NAD(P)H dehydrogenase, quinone 1 | electron transport / nitric oxide biosynthesis / response to toxin / synaptic transmission, cholinergic / xenobiotic metabolism | NAD(P)H dehydrogenase (quinone) activity / cytochrome-b5 reductase activity / oxidoreductase activity | cytoplasm | --- |
| TXNRD1 | 39425_at | 3.33 | 0.02 | thioredoxin reductase 1 | electron transport / signal transduction | disulfide oxidoreductase activity / metal ion binding / thioredoxin-disulfide reductase activity | cytoplasm | Pyrimidine metabolism |
| CYP1B1 | 40071_at | 3.33 | 0.03 | cytochrome P450, family 1, subfamily B, polypeptide 1 | electron transport / eye morphogenesis (sensu Mammalia) / visual perception | electron transporter activity / monooxygenase activity / oxygen binding | endoplasmic reticulum / membrane / microsome | --- |
| CYP1A1 | 1025_g_at | 2.50 | 0.01 | cytochrome P450, family 1, subfamily A, polypeptide 1 | electron transport | monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding | endoplasmic reticulum / membrane / microsome | Fatty acid metabolism / gamma-Hexachlorocy clohexane degradation / Tryptophan metabolism |
| CYP1B1 | 859_at | 2.50 | 0.03 | cytochrome P450, family 1, subfamily B, polypeptide 1 | electron transport / eye morphogenesis (sensu Mammalia) / visual perception | electron transporter activity / monooxygenase activity / oxygen binding | endoplasmic reticulum / membrane / microsome | --- |
| PGD | 36963_at | 2.00 | 0.003 | phosphogluconate dehydrogenase | pentose-phosphate shunt, oxidative branch | electron transporter activity / oxidoreductase activity / phosphogluconate dehydrogenase (decarboxylating) activity | --- | Pentose_Phos phate_Pathwa y / Pentose phosphate pathway |
| CYP1A1 | 36767_at | 2.00 | 0.01 | cytochrome P450, family 1, subfamily A, polypeptide 1 | electron transport | monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding | endoplasmic reticulum / membrane / microsome | Fatty acid metabolism / gamma-Hexachlorocy clohexane degradation / Tryptophan metabolism |
| SQSTM1 | 40898_at | 2.00 | 0.05 | sequestosome 1 | endosome transport / intracellular signaling cascade / positive regulation of transcription from Pol II promoter / protein localization / regulation of I-kappaB kinase/NF-kappaB cascade / response to stress | SH2 domain binding / protein kinase binding / ubiquitin binding / zinc ion binding | cytosol | --- |
| ETFB | 36881_at | 1.43 | 0.02 | electron-transfer-flavoprotein, beta polypeptide | electron transport | electron carrier activity | mitochondrial matrix | --- |
| NQO2 | 36880_at | 1.25 | 0.01 | NAD(P)H dehydrogenase, quinone 2 | electron transport | NAD(P)H dehydrogenase (quinone) activity / NADPH dehydrogenase (quinone) activity / electron transporter activity / oxidoreductase activity | --- | Biosynthesis of steroids |
| P2RX5 | 40396_at | 1.25 | 0.01 | purinergic receptor P2X, ligand-gated ion channel, 5 | ion transport | ATP binding / ion channel activity / receptor activity | membrane | --- |
| ATP1B1 | 37669_s_at | 1.25 | 0.02 | ATPase, Na+/K+ transporting, beta 1 polypeptide | potassium ion transport / sodium ion transport / transport | sodium:potassium-exchanging ATPase activity | integral to membrane / sodium:potassi um-exchanging ATPase complex | --- |
| TOM1 | 39134_at | 1.25 | 0.02 | target of myb1 (chicken) | endocytosis / endosome transport / intra-Golgi transport / intracellular protein transport | protein binding / protein transporter activity | Golgi stack / cytosol / early endosome / endosome / lysosome / membrane | --- |
| COG2 | 38390_at | 1.25 | 0.02 | component of oligomeric golgi complex 2 | Golgi organization and biogenesis / intra-Golgi transport / intracellular protein transport / oligosaccharide biosynthesis / protein amino acid glycosylation | protein transporter activity | Golgi membrane / Golgi transport complex / membrane | --- |
| CYP1A1 | 1024_at | 1.25 | 0.04 | cytochrome P450, family 1, subfamily A, polypeptide 1 | electron transport | monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding | endoplasmic reticulum / membrane / microsome | Fatty acid metabolism / gamma-Hexachlorocy clohexane degradation / Tryptophan metabolism |
| NAPA | 36977_at | 1.25 | 0.04 | N-ethylmaleimide-sensitive factor attachment protein, alpha | intra-Golgi transport / intracellular protein transport / membrane fusion | intracellular transporter activity | Golgi apparatus / endoplasmic reticulum | --- |
| AP2A2 | 32228_at | 1.11 | 0.0005 | adaptor-related protein complex 2, alpha 2 subunit | endocytosis / intracellular protein transport / protein complex assembly | lipid binding / structural molecule activity | AP-2 adaptor complex / Golgi apparatus / clathrin coat of trans-Golgi network vesicle / coated pit | --- |
| SEC23IP | 34896_at | 1.11 | 0.003 | SEC23 interacting protein | Golgi organization and biogenesis / intracellular protein transport | metal ion binding / protein binding | ER-Golgi intermediate compartment | --- |
| NDUFS8 | 38257_at | 1.11 | 0.004 | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) | electron transport / mitochondrial electron transport, NADH to ubiquinone | NADH dehydrogenase (ubiquinone) activity / NADH dehydrogenase activity / electron carrier activity / iron ion binding | membrane fraction / mitochondrion | Electron_Tran sport_Chain |
| SLC25A16 | 33262_at | 0.91 | 0.003 | solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 | transport | binding / solute:solute antiporter activity | integral to membrane / mitochondrial inner membrane / mitochondrion | --- |
| KIAA0882 | 38254_at | 0.91 | 0.02 | KIAA0882 protein | --- | calcium ion binding | --- | --- |
| TMP21 | 36128_at | 0.91 | 0.02 | transmembrane trafficking protein | ER to Golgi transport / protein transport | --- | Golgi apparatus / integral to plasma membrane / membrane fraction / microsome | --- |
| EGFL5 | 36488_at | 0.91 | 0.02 | EGF-like-domain, multiple 5 | --- | calcium ion binding / structural molecule activity | integral to membrane | --- |
| IVD | 37342_s_at | 0.91 | 0.03 | isovaleryl Coenzyme A dehydrogenase | electron transport | isovaleryl-CoA dehydrogenase activity / oxidoreductase activity | mitochondrial matrix | Valine, leucine and isoleucine degradation |
| SLC30A3 | 34457_at | 0.91 | 0.05 | solute carrier family 30 (zinc transporter), member 3 | cation transport / transport / zinc ion transport | cation transporter activity / zinc porter activity | endosome / integral to plasma membrane / membrane / membrane fraction / synaptic vesicle | --- |
| SLC30A1 | 34759_at | 0.83 | 0.005 | solute carrier family 30 (zinc transporter), member 1 | cation transport / transport / zinc ion transport | cation transporter activity | integral to membrane | --- |
| ITPR1 | 32778_at | 0.83 | 0.01 | inositol 1,4,5-triphosphate receptor, type 1 | calcium ion transport / cation transport / signal transduction | calcium channel activity / inositol 1,4,5-triphosphate-sensitive calcium-release channel activity / inositol-1,4,5-triphosphate receptor activity | Endoplasmic reticulum membrane / integral to membrane | Calcium_Channels / G_Protein_Si gnaling |
| TM9SF2 | 34307_at | 0.83 | 0.02 | transmembrane 9 superfamily member 2 | transport | transporter activity | endosome / integral to plasma membrane | --- |
| KCNK1 | 37552_at | 0.83 | 0.04 | potassium channel, subfamily K, member 1 | ion transport / potassium ion transport | inward rectifier potassium channel activity / potassium channel activity / voltage-gated ion channel activity | integral to membrane / membrane fraction / voltage-gated potassium channel complex | --- |
| NNT | 41722_at | 0.77 | 0.003 | nicotinamide nucleotide transhydrogenase | electron transport / energy pathways / proton transport | NAD(P)+ transhydrogenase (AB-specific) activity / NAD(P)+ transhydrogenase (B-specific) activity / electron transporter activity / oxidoreductase activity | integral to membrane / mitochondrial electron transport chain / mitochondrion | --- |
| TUSC3 | 36851_g_at | 0.77 | 0.01 | tumor suppressor candidate 3 | electron transport | electron transporter activity | integral to membrane | --- |
| ITPR1 | 755_at | 0.77 | 0.01 | inositol 1,4,5-triphosphate receptor, type 1 | calcium ion transport / cation transport / signal transduction | calcium channel activity / inositol 1,4,5-triphosphate-sensitive calcium-release channel activity / inositol-1,4,5-triphosphate receptor activity | endoplasmic reticulum membrane / integral to membrane | Calcium_Cha nnels / G_Protein_Si gnaling |
| ARL6IP | 36572_r_at | 0.71 | 0.002 | ADP-ribosylation factor-like 6 interacting protein | --- | --- | integral to membrane | --- |
| FNBP2 | 36069_at | 0.63 | 0.02 | formin binding protein 2 | metal ion transport | GTPase activator activity / metal ion binding | --- | --- |