Table 6.
DNA Repair-Associated Genes
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| FLJ22028 | 34685_at | 1.43 | 0.04 | hypothetical protein FLJ22028 | DNA repair | ATP binding / ATP-dependent DNA helicase activity / DNA binding / hydrolase activity | nucleus | --- |
| MPG | 37768_at | 1.25 | 0.01 | N-methylpurine-DNA glycosylase | DNA dealkylation / base-excision repair | alkylbase DNA N-glycosylase activity / damaged DNA binding / hydrolase activity | nucleoplasm | --- |
| CSNK1D | 493_at | 1.25 | 0.02 | casein kinase 1, delta | DNA repair / Wnt receptor signaling pathway / protein amino acid phosphorylation / signal transduction | ATP binding / casein kinase I activity / protein serine/threonine kinase activity / transferase activity | --- | --- |
| MAPK12 | 984_g_at | 1.25 | 0.02 | mitogen-activated protein kinase 12 | DNA damage induced protein phosphorylation / MAPKKK cascade / cell cycle / cell cycle arrest / muscle development / myoblast differentiation / negative regulation of cell cycle / signal transduction | ATP binding / MAP kinase activity / SAP kinase 3 activity / magnesium ion binding / protein serine/threonine kinase activity / transferase activity | cytoplasm | MAPK_Cascade / S1P_Signaling / Integrin-mediated_cell_adh esion |
| ADPRTL1 | 37303_at | 1.11 | 0.004 | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 | DNA repair / inflammatory response / necrosis / protein amino acid ADP-ribosylation / response to drug / transport | NAD+ ADP-ribosyltransferase activity / transferase activity, transferring glycosyl groups | nucleus / ribonucleopr otein complex | --- |
| TSN | 36177_at | 1.11 | 0.01 | translin | DNA recombination | DNA binding | nucleus | --- |
| DDB1 | 1641_s_at | 1.11 | 0.02 | damage-specific DNA binding protein 1, 127kDa | nucleotide-excision repair | damaged DNA binding | nucleus | --- |
| HMGB1 | 32220_at | 0.91 | 0.0002 | high-mobility group box 1 | DNA recombination / DNA repair / DNA unwinding / base-excision repair, DNA ligation / establishment and/or maintenance of chromatin architecture / negative regulation of transcriptional preinitiation complex formation / regulation of transcription from Pol II promoter | DNA bending activity / transcription factor binding | chromatin / condensed chromosome / nucleus | --- |
| XRCC5 | 38733_at | 0.83 | 0.002 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) | DNA recombination / double-strand break repair via nonhomologous end-joining / regulation of DNA repair | ATP-dependent DNA helicase activity / double-stranded DNA binding / helicase activity | DNA-dependent protein kinase complex / nucleus | --- |
| CHEK2 | 37887_at | 0.83 | 0.03 | CHK2 checkpoint homolog (S. pombe) | DNA damage checkpoint / cell cycle / cell growth and/or maintenance / protein amino acid phosphorylation / response to DNA damage stimulus | ATP binding / protein kinase activity / protein serine/threonine kinase activity / transferase activity | nucleus | Cell_cycle |
| MBD4 | 34386_at | 0.83 | 0.05 | methyl-CpG binding domain protein 4 | base-excision repair | endodeoxyribonuclease activity / hydrolase activity / satellite DNA binding | nucleus | --- |
| HMGB2 | 38065_at | 0.53 | 0.02 | high-mobility group box 2 | DNA repair / DNA replication / DNA unwinding / base-excision repair, DNA ligation / establishment and/or maintenance of chromatin architecture / nucleosome assembly / regulation of transcription from Pol II promoter | DNA bending activity / double-stranded DNA binding / single-stranded DNA binding / transcription factor activity | chromatin / condensed chromosome / nuclear chromosome / perinuclear region | --- |