Table 7.
Apoptosis-Related Genes
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| TP53I3 | 36079_at | 1.43 | 0.02 | tumor protein p53 inducible protein 3 | induction of apoptosis by oxidative stress | alcohol dehydrogenase activity, zinc-dependent / zinc ion binding | --- | --- |
| IER3 | 1237_at | 1.25 | 0.03 | immediate early response 3 | anti-apoptosis / apoptosis / cell growth and/or maintenance / morphogenesis | --- | integral to membrane | --- |
| MAEA | 32832_at | 1.11 | 0.02 | macrophage erythroblast attacher | apoptosis / cell adhesion / development | --- | integral to plasma membrane / membrane fraction | --- |
| PTK2B | 33804_at | 1.11 | 0.02 | PTK2B protein tyrosine kinase 2 beta | apoptosis / cell adhesion / positive regulation of cell proliferation / protein amino acid phosphorylation / protein complex assembly / response to stress / signal complex formation / signal transduction | ATP binding / non-membrane spanning protein tyrosine kinase activity / signal transducer activity / transferase activity | cytoskeleton | --- |
| MAP2K4 | 1845_at | 1.11 | 0.01 | mitogen-activated protein kinase kinase 4 | JNK cascade / protein amino acid phosphorylation / signal transduction | ATP binding / protein serine/threonine kinase activity / protein-tyrosine kinase activity / transferase activity | --- | Apoptosis / MAPK_Cascad e |
| DFFA | 32047_at | 1.11 | 0.04 | DNA fragmentation factor, 45kDa, alpha polypeptide | DNA fragmentation during apoptosis / apoptosis / intracellular signaling cascade | caspase-activated deoxyribonuclease activity / protein binding | cytosol / nucleus | Apoptosis |
| TRADD | 1729_at | 1.11 | 0.005 | TNFRSF1A–associated via death domain | apoptosis / induction of apoptosis / positive regulation of I-kappaB kinase/NF-kappaB cascade / signal transduction | protein binding / signal transducer activity | --- | Apoptosis |
| HDAC3 | 35821_at | 1.11 | 0.01 | histone deacetylase 3 | anti-apoptosis / chromatin modification / histone deacetylation / regulation of cell cycle / regulation of transcription, DNA-dependent | histone deacetylase activity / hydrolase activity / transcription factor binding | cytoplasm / histone deacetylase complex / nucleus | Cell_cycle |
| DAXX | 1754_at | 1.11 | 0.02 | death-associated protein 6 | apoptosis / regulation of transcription, DNA-dependent | calcium ion binding | nucleus | Apoptosis |
| RTN4 | 31536_at | 0.91 | 0.02 | reticulon 4 | negative regulation of anti-apoptosis / negative regulation of axon extension / regulation of apoptosis | protein binding | endoplasmic reticulum / integral to endoplasmic reticulum membrane / nuclear membrane | --- |
| PORIMIN | 40803_at | 0.71 | 0.002 | pro-oncosis receptor inducing membrane injury gene | --- | receptor activity | integral to membrane | --- |