Table 9.
Genes involved in Cell Cycle Regulation
| Gene symbol | Probe set | Ratio CSE/Con | p-value | Description | GO Biological Process | GO Molecular Function | GO Cellular Component | Pathway |
|---|---|---|---|---|---|---|---|---|
| BMP2 | 40367_at | 1.25 | 0.04 | bone morphogenetic protein 2 | cell growth and/or maintenance / cell-cell signaling / growth / skeletal development | cytokine activity / growth factor activity | extracellular | --- |
| CDK8 | 1189_at | 1.25 | 0.05 | cyclin-dependent kinase 8 | cytokinesis / protein amino acid phosphorylation / regulation of cell cycle / regulation of transcription, DNA-dependent | ATP binding / protein serine/threonine kinase activity / transferase activity | --- | --- |
| CCNE1 | 41060_at | 1.11 | 0.01 | cyclin E1 | G1/S transition of mitotic cell cycle / cytokinesis / regulation of cell cycle | --- | nucleus | Cell_cycle |
| MSF | 41220_at | 1.11 | 0.03 | MLL septin-like fusion | cell cycle | GTP binding | --- | --- |
| PMS2 | 38556_at | 1.11 | 0.03 | PMS2 postmeiotic segregation increased 2 (S.cerevisiae) | mismatch repair / negative regulation of cell cycle | ATP binding / DNA binding | nucleus | --- |
| MDK | 38124_at | 1.11 | 0.03 | midkine (neurite growth-promoting factor 2) | cell differentiation / cell proliferation / cell-cell signaling / neurogenesis / regulation of cell cycle / signal transduction | cytokine activity / growth factor activity / heparin binding | extracellular space | --- |
| RASSF1 | 39601_at | 0.91 | 0.005 | Ras association (RalGDS/AF-6) domain family 1 | Ras protein signal transduction / cell cycle / cell cycle arrest / intracellular signaling cascade / negative regulation of cell cycle | diacylglycerol binding / protein binding / zinc ion binding | microtubule cytoskeleton / nucleus | --- |
| CDKN2C | 36053_at | 0.91 | 0.01 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | cell cycle / cell cycle arrest / negative regulation of cell proliferation | cyclin-dependent protein kinase inhibitor activity | cytoplasm / nucleus | --- |
| MTM1 | 36920_at | 0.91 | 0.02 | myotubular myopathy 1 | cell growth and/or maintenance / muscle development / protein amino acid dephosphorylation | hydrolase activity / protein serine/threonine phosphatase activity / protein tyrosine phosphatase activity | --- | --- |
| MLLT10 | 33773_at | 0.91 | 0.03 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | cell growth and/or maintenance / regulation of transcription, DNA-dependent | transcription factor activity | nucleus | --- |
| FLJ14001 | 40530_at | 0.91 | 0.03 | hypothetical protein FLJ14001 | G2/M transition of mitotic cell cycle / cytokinesis / mitosis / regulation of cell cycle | --- | nucleus | --- |
| YES1 | 1674_at | 0.91 | 0.04 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | cell growth and/or maintenance / intracellular signaling cascade / protein amino acid phosphorylation | ATP binding / protein-tyrosine kinase activity / transferase activity | --- | --- |
| FHIT | 1992_at | 0.91 | 0.04 | fragile histidine triad gene | cell cycle / negative regulation of cell cycle / nucleotide metabolism | bis(5’-adenosyl)-triphosphatase activity / hydrolase activity / magnesium ion binding / manganese ion binding | cytoplasm | Purine metabolism |
| JUN | 1895_at | 0.83 | 0.004 | v-jun sarcoma virus 17 oncogene homolog (avian) | cell growth and/or maintenance / regulation of transcription, DNA-dependent | RNA polymerase II transcription factor activity / transcription factor activity | nuclear chromosome | Apoptosis / MAPK_Cascade / TGF_Beta_Signali ng_Pathway / Wnt_signaling |
| KATNA1 | 32708_g_at | 0.83 | 0.01 | katanin p60 (ATPase-containing) subunit A 1 | mitosis | ATP binding / nucleotide binding | cytoskeleton | --- |
| STMN1 | 1782_s_at | 0.83 | 0.02 | stathmin 1/oncoprotein 18 | cell growth and/or maintenance / intracellular signaling cascade | signal transducer activity | cytosol | --- |
| CCND2 | 36650_at | 0.77 | 0.01 | cyclin D2 | cytokinesis / regulation of cell cycle | --- | nucleus | Ovarian_Infertilit y_Genes / Wnt_signaling / Cell_cycle |
| CDK2 | 1792_g_at | 0.77 | 0.02 | cyclin-dependent kinase 2 | G2/M transition of mitotic cell cycle / cell cycle / cytokinesis / mitosis / positive regulation of cell proliferation / protein amino acid phosphorylation / regulation of DNA replication / traversing start control point of mitotic cell cycle | ATP binding / cyclin-dependent protein kinase activity / protein serine/threonine kinase activity / transferase activity | cytoplasm / nucleus | DNA_replication / Cell_cycle |
| KRAS2 | 1940_at | 0.77 | 0.03 | v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog | cell growth and/or maintenance / regulation of cell cycle / small GTPase mediated signal transduction | GTP binding / GTPase activity | --- | G_Protein_Signal ing / MAPK_Cascade |
| WEE1 | 36909_at | 0.63 | 0.01 | WEE1 homolog (S. pombe) | mitosis / protein amino acid phosphorylation / regulation of cell cycle | ATP binding / protein serine/threonine kinase activity / protein-tyrosine kinase activity / transferase activity | nucleus | Cell_cycle |
| TTK | 572_at | 0.63 | 0.04 | TTK protein kinase | mitotic spindle assembly / mitotic spindle checkpoint / positive regulation of cell proliferation / protein amino acid phosphorylation / regulation of cell cycle | ATP binding / protein serine/threonine kinase activity / protein-tyrosine kinase activity / transferase activity | spindle | --- |
| KNTC2 | 40041_at | 0.53 | 0.05 | kinetochore associated 2 | mitosis / mitotic sister chromatid segregation | --- | chromosome, pericentric region / nucleus | --- |