Table 2.
Allelic and genotypic frequency of (-670 A/G) Apo1/Fas gene polymorphisms in patients with inflammatory bowel disease and controls n (%)
ApoI/Fas (-670) | Controls (n = 100) | IBD (n = 164) | UC (n = 59) | CD (n = 105) |
Genotypic frequencies | ||||
A/A | 49 (49) | 46 (28.04)c | 15 (25.42)b | 31 (29.52)a |
A/G | 32 (32) | 70 (42.68) | 30 (50.85) | 40 (38.10) |
G/G | 19 (19) | 48 (29.26) | 14 (23.73) | 34 (32.38) |
Allelic frequencies | ||||
A | 130 (70)e | 162 (49.39)d | 60 (50.84)f | 102 (48.57)e |
G | 70 (35) | 166 (50.61) | 58 (49.16) | 108 (51.43) |
Comparing AA genotype frequencies in CD patients with controls: P corrected = 0.004, OR: 0.44, 95% CI, 0.24 < OR < 0.81;
Comparing AA genotype frequencies in UC patients with controls: P corrected = 0.0034, OR: 0.35, 95% CI, 0.16 < OR < 0.76;
Comparing AA genotype frequencies in IBD patients with controls: P corrected = 0.0005, OR: 0.41, 95% CI, 0.23 < OR < 0.70;
Comparing A/Allele frequencies in IBD patients with controls: P corrected = 0.0004, OR: 0.53, 95% CI, 0.36 < OR < 0.77;
Comparing A/Allele frequencies in CD patients with controls: P corrected = 0.0007, OR: 0.57, 95% CI, 0.34 < OR < 0.77;
Comparing A/Allele frequencies in UC patients with controls: P corrected = 0.01, OR: 0.56, 95% CI, 0.34 < OR < 0.91. IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn’s disease; OR: Odds ratio; CI: Confidence interval.