Figure 2.

Modes of neurite growth inhibition of molecules expressed on CNS myelin and oligodendrocytes. RGM A has two modes of inducing growth inhibition: a trans-mode, with RGM A on myelin/oligodendrocytes binding to neuronal Neogenin and downstream activation of the Rho-Rho-kinase pathway. LMO4 is a transcriptional co-regulator, present in neurites and growth cones, stimulating the Rho pathway via an unknown mechanism. In the cis mode, RGM A expressed on neurites interacts with BMP-2/BMP-4. This complex then stimulates LIM-Kinase via activation of BMP-receptors I and II, leading to axonal growth inhibition (Figure 2 is a courtesy of Dr T. Yamashita, University of Osaka, Japan).