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Phase II oral vorinostat: intent to treat response of 24% (8/33)
| 400 mg qd (n = 13) | 300 mg bid × 3–5 d/wk (n = 11) | 300 mg bid × 2w 400 mg qd (n = 9) | |
|---|---|---|---|
| Partial response | 4 (31%) | 1 (9%) | 3 (33%) |
| Marked (patients) | 2 | 1 | 3 |
| Median PR duration (range/weeks) | 15 (8–24) | 16 (8–24) | 13 (3–21) |
| Mean time to PR (weeks) | 11 | 4 | 11 |
| LN regression at 4 wks (patients) | 7 of 9 | 3 of 8 | 5 of 9 |
| >50%↓ pruritus (patients) | 9 of 11 | 8 of 12 | 4 of 8 |
Abbreviations: LN, lymph node; PR, partial response.
