Table 4.

Oral vorinostat dosing and dose modification schedule

Treatment group	Dosing schedule	First dose reduction	Second dose reduction
1	400 mg every day*	350 mg every day	300 mg every day
2	300 mg twice daily × 3 d per wk × 4 wk, then 5 d every wk	250 mg × 3 d/wk	200 mg twice daily × 3 d/wk
3	Ind: 300 mg twice daily × 14 d with7 d rest; mtnc; 200 mg twice daily	200 mg twice daily	200 mg twice daily × 5 d/wk

Abbreviation: Ind, indicates induction; mtnc, maintenance.

^*Initial 3 patients treated at 250 mg/m²/day