Table 5.
400 mg qd (n = 13) | 300 mg bid × 3–5 d/wk (n = 11) | 300 mg bid 400 mg qd (n = 9) | |
---|---|---|---|
Partial response | 4 (31%) | 1 (9%) | 3 (33%) |
marked (patients) | 2 | 1 | 3 |
Median PR duration (range/weeks) | 15 (8–24) | 16 (8–24) | 13 (3–21) |
Mean time to PR (weeks) | 11 | 4 | 11 |
LN regression at 4 wks (patients) | 7 of 9 | 3 of 8 | 5 of 9 |
>50%↓ pruritus (patients) | 9 of 11 | 8 of 12 | 4 of 8 |
Phase 2A
Abbreviations: LN, lymph node; PR, partial response.