Table 4.

Effect of dexamethasone and EIAEDs on the pharmacokinetics of CPT-11 and its metabolites

		Low CPT-11 dose (100/125 mg/m2)				High CPT-11 dose (250/300 mg/m2)
		None (n = 1)	Dex alone (n = 3)	EIAED alone n = 4)	Dex + EIAED (n = 19)	None (n = 3)	Dex alone (n = 6)	EIAED alone (n = 9)	Dex + EIAED (n = 12)
CPT-11	Cmax	1010	2090 ± 1490	1180 ± 590	2160 ± 3270	2200 ± 610	2630 ± 670	1990 ± 688	2380 ± 1110
	AUC	6710	7890 ± 2720	4930 ± 1380	5870 ± 4130	15,300 ± 5700	16,400 ± 3600	11,400 ± 4700	10,500 ± 3200
	Cl	12.7	12.1 ± 2.5	20.8 ± 5.6	21.7 ± 10.5	15.3 ± 6.1	13.9 ± 3.9	21.6 ± 8.2	23.9 ± 6.6
	t1/2	5.3	6.5 ± 0.9	5.0 ± 0.3	5.3 ± 0.7	5.4 ± 0.4	6.3 ± 0.9	5.1 ± 0.5	5.1 ± 0.7
APC	Cmax	153	142 ± 110	127 ± 12	162 ± 101	401 ± 39	380 ± 113	359 ± 134	432 ± 100
	AUC	1710	1860 ± 1610	1520 ± 297	1670 ± 1080	5010 ± 500	4720 ± 1580	4260 ± 1600	4610 ± 1740
	t1/2	5.7	7.8 ± 2.1	5.5 ± 0.9	5.7 ± 0.9	6.0 ± 0.5	6.7 ± 2.3	6.0 ± 0.6	5.5 ± 1.1
SN-38	Cmax	21.6	17.4 ± 2.3	11.1 ± 2.8	12.1 ± 5.0	25.7 ± 24.7	39.4 ± 24.4	15.9 ± 6.4	16.6 ± 4.4
	AUC	208	136 ± 34	85 ± 19	63 ± 33	232 ± 138	367 ± 218	150 ± 85	118 ± 44
	t1/2	17.1	17.5 ± 4.0	10.4 ± 1.7	14.5 ± 12.1	12.1 ± 2.2	19.0 ± 5.8	11.7 ± 3.0	11.1 ± 3.3
SN-38G	Cmax	34.4	64.5 ± 31.3	46.3 ± 14.1	57.7 ± 22.0	78.6 ± 30.4	137.3 ± 63.0	97.4 ± 18.0	90.9 ± 18.0
	AUC	418	692 ± 367	377 ± 160	422 ± 216	828 ± 288	1558 ± 720	839 ± 240	658 ± 171
	t1/2	13.5	16.6 ± 9.4	9.9 ± 2.8	9.1 ± 2.0	13.0 ± 1.4	14.6 ± 3.6	9.7 ± 1.5	9.8 ± 3.9