Percentage of patients who had PPTD (left) and hypothyroidism (right) develop in TPOAb(+) women who received Se (group S1) or placebo (group S0), and in TPOAb(−) women (group C)., P < 0.01 copyright © 2007. The Endocrine Society. Reproduced with permission from Negro R, Greco G, Mangieri T, et al. 2007. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab, 92:1263–8.