Table 2.

Types of mutations in the protein C gene causing protein C deficiency

Mutation	Frequency n (%)
Missense/nonsense	170 (72.0)
Splicing	22 (9.3)
Regulatory	11 (4.7)
Small deletions	20 (8.5)
Small insertions	10 (4.2)
Small indels	1 (0.4)
Gross deletions	2 (0.8)
Gross insertions	0
Complex rearrangements	0
Repeat variations	0
Total	236

According to the Human Gene Mutation Database at Institute of Medical Genetics in Cardiff (http://www.hgmd.cf.ac.uk/ac/gene.php?gene=PROC).