Table 1.

Overview of animal models of scleroderma and comparison with immunological and clinical features of human scleroderma

	Human scleroderma	GVH SSc in BALB/c mice	UCD-200 chickens	Bleomycin-induced scleroderma	TSK/+ mice
Autoantibodies	+	+	+	+	+
Vasculopathy	+	+	+	−	+
Fibrosis
Skin	+	+	+	+	+
Internal	+	+	+	+	−
Inflammation	+	+	+	+	−

Abbreviations: GVH SSc, graft-versus-host systemic sclerosis; TSK, tight-skin; UCD, University of California, Davis.