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. 2008 Sep;2(3):345–354. doi: 10.2147/btt.s3394

Figure 1.

Figure 1

Cell signaling in chemotaxis and cell proliferation during wound-healing: Platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-β) play an integral role in the signal cascade responsible for chemotaxis and cell migration during wound-healing. The recruitment of osteoprogenitor cells and their proliferation provides a pool of cells that will respond to bone morphogenic protein (BMP). Reproduced with permission from Hollinger JO, et al 2008. Recombinant human platelet-derived growth factor: biology and clinical applications. J Bone Joint Surg Am, 90:48–54. Copyright © 2008. The Journal of Bone and Joint Surgery, Inc.