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Key pathways in hepatocarcinogenesis and molecularly targeted agents currently under investigation in treatment of advanced HCC. Adapted with permission from Gollob JA, Wilhelm S, Carter C, et al. 2006. Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol, 33:392–406. Copyright © 2006 Elsevier.
