Table 1.
Baseline clinical characteristics by uric acid levels in non-CKD and CKD populations in the ARIC cohort
| Characteristic | Non-CKD (GFR ≥ 60 ml/min/1.73 m2) | CKD (GFR < 60 ml/min/1.73 m2) | ||
|---|---|---|---|---|
| Normal serum uric acid (N = 9745) | High serum uric acida (N = 5160) | Normal serum uric acid (N = 139) | High serum uric acida (N = 322) | |
| GFR (ml/min/1.73 m2) | 95 ± 17 | 90 ± 17 | 52 ± 10 | 49 ± 12 |
| Serum uric acid (mg/dl) | 5.2 ± 0.9 | 7.6 ± 1.1 | 5.3 ± 0.9 | 8.3 ± 1.6 |
| Demographics | ||||
| Age (years) | 54 ± 5 | 55 ± 5 | 56 ± 6 | 57 ± 5 |
| Gender (% women)b | 57 | 49 | 69 | 60 |
| Race (%African Americans) | 22 | 33 | 11 | 31 |
| Clinical characteristics | ||||
| Diabetes (%) | 9 | 14 | 16 | 29 |
| Metabolic syndromec (%) | 20 | 48 | 29 | 59 |
| Coronary artery disease (%) | 4 | 7 | 10 | 18 |
| Cerebrovascular disease (%)b,d | 4 | 5 | 9 | 10 |
| Congestive heart failure (%)b | 7 | 11 | 16 | 21 |
| Peripheral vascular disease (%) | 2 | 3 | 2 | 7 |
| Cancer (%)b,d | 5 | 5 | 8 | 6 |
| Past or current smoking (%)b | 56 | 60 | 62 | 56 |
| Past or current alcohol intake (%) | 74 | 74 | 77 | 65 |
aHigh serum acid was defined as >7 mg/dl in men and >6 mg/dl in women. bP-value not significant for the comparison of the low and high uric acid groups in CKD.
cMetabolic syndrome was defined as the presence of three out of five following components–-abdominal obesity, hypertriglyceridaemia, decreased HDL cholesterol, hypertension and insulin resistance.
dP-value not significant for the comparison of the low and high uric acid groups in non-CKD.
All other P-value <0.05.