Table 4.

Associations of the high uric acid group (with the normal uric acid group as the reference) with cardiovascular events or mortality adjusted for metabolic syndrome or its components in the non-CKD and CKD sub-groups in the ARIC cohort

	Non-CKD cohort [HR (95% CI)]		CKD cohort [HR (95% CI)]
	CV events	Death	CV events	Death
Model C	1.27 (1.13–1.43)	1.27 (1.13–1.43)	0.91 (0.57–1.46)	1.37 (0.84–2.23)
Model C + metabolic syndrome	1.07 (0.96–1.19)	1.18 (1.04–1.33)	0.82 (0.50–1.33)	1.28 (0.79–2.09)
Model C + hypertension	1.12 (1.01–1.24)	1.19 (1.06–1.34)	0.85 (0.53–1.37)	1.31 (0.81–2.14)
Model C + insulin resistance	1.19 (1.07–1.32)	1.22 (1.08–1.37)	0.84 (0.52–1.35)	1.31 (0.80–2.13)
Model C + abdominal obesity	1.21 (1.09–1.34)	1.26 (1.12–1.42)	1.21 (1.09–1.34)	1.37 (0.84–2.23)
Model C + hypertriglyceridaemia	1.16 (1.05–1.29)	1.23 (1.09–1.38)	0.85 (0.53–1.37)	1.31 (0.80–2.14)
Model C + low HDL cholesterol	1.16 (1.05–1.29)	1.23 (1.09–1.38)	0.93 (0.57–1.50)	1.33 (0.81–2.18)

Model C—same as in Table 3, i.e. adjusted for age, race, sex, coronary artery disease, cerebrovascular disease, heart failure, peripheral vascular disease, cancer, smoking, alcohol and GFR.