Skip to main content
. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Neuroscientist. 2008 Dec;14(6):609–625. doi: 10.1177/1073858408322675

Fig. 8. Developmental and activity-dependent regulation of preNMDAR functions.

Fig. 8

Presynaptic NR2B–containing receptors enhance spontaneous release in the entorhinal cortex of young rats and epileptic adults, but not in normal adults. (A–C) Voltage-clamp recordings of sEPSCs in a layer 5 neurons in a slice from (A) a 4-week-old rat, (B) a 5-month-old rat, and (C) and a 5-month-old epileptic rat. Blockade of NR2B receptors with Ro 25–6981 decreases the frequency of sEPSCs only in young and epileptic rats. Postsynaptic NMDARs are blocked by intracellular MK-801. (D–F) Corresponding pooled data for inter-event interval of the sEPSCs from control and Ro 25–6981 recordings. Reproduced with permission from Yang and others (2006).