Table 2.
Baseline measures by uncarboxylated matrix Gla protein (ucMGP) tertiles
| ucMGP (nM) | ||||
|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | ||
| Characteristics | <2766 (n = 282) | 2766–3650 (n = 280) | >3650 (n = 280) | P-value |
| Demographics | ||||
| Age (year) | 71 (63–79) | 68 (60–76) | 64 (56–71) | <0.001 |
| Male sex, no. (%) | 239 (85) | 227 (81) | 219 (78) | 0.14 |
| Race | 0.56 | |||
| Caucasian, no. (%) | 180 (64) | 176 (60) | 159 (57) | |
| African American, no. (%) | 42 (15) | 47 (17) | 47 (17) | |
| Other, no. (%) | 60 (21) | 65 (23) | 73 (26) | |
| Regular alcohol use, no. (%) | 70 (25) | 76 (27) | 94 (34) | 0.06 |
| Regular tobacco use, no. (%) | 44 (16) | 61 (22) | 66 (24) | 0.05 |
| Body mass index (kg/m2)a | 27 (24–30) | 27 (25–31) | 29 (26–33) | <0.001 |
| Medical history | ||||
| Hypertension, no. (%) | 193 (69) | 211 (75) | 200 (72) | 0.26 |
| Diabetes, no. (%) | 57 (20) | 74 (27) | 91 (33) | 0.01 |
| Myocardial infarction, no. (%) | 159 (57) | 141 (51) | 147 (53) | 0.33 |
| Angioplasty, no. (%) | 105 (38) | 108 (39) | 115 (41) | 0.64 |
| Coronary bypass, no. (%) | 107 (38) | 108 (39) | 91 (33) | 0.30 |
| Heart failure, no. (%) | 45 (16) | 54 (19) | 52 (19) | 0.57 |
| Medication use | ||||
| Anticoagulant/thrombolytic, no. (%) | 20 (7) | 20 (7) | 23 (8) | 0.85 |
| Measurements | ||||
| SBP (mmHg) | 132 (22) | 135 (22) | 133 (20) | 0.10 |
| DBP (mmHg) | 72 (10) | 75 (12) | 76 (11) | <0.001 |
| Albumin (g/dL)a | 3.8 (3.6–4.0) | 3.9 (3.7–4.1) | 4.0 (3.8–4.2) | <0.001 |
| Calcium (mg/dL) | 9.4 (0.5) | 9.5 (0.5) | 9.6 (0.5) | <0.001 |
| Phosphorus (mg/dL)a | 3.6 (3.2–3.9) | 3.7 (3.3–4.0) | 3.7 (3.3–4.1) | 0.02 |
| Fetuin-A (g/L)a | 0.60 (0.52–0.68) | 0.64 (0.57–0.73) | 0.68 (0.60–0.79) | <0.001 |
| Glucose (fasting) (mg/dL)a | 104 (95–117) | 108 (99–123) | 111 (101–137) | <0.001 |
| Cholesterol (mg/dL)a | 163 (143–186) | 169 (145–191) | 181 (157–210) | <0.001 |
| HDL (mg/dL) | 47 (14) | 45 (14) | 46 (14) | 0.34 |
| Triglycerides (mg/dL)a | 88 (63–136) | 111 (79–157) | 130 (87–207) | <0.001 |
| CRP (mcg/dL)a | 2.27 (1.00–4.92) | 2.21 (0.84–5.43) | 2.32 (1.01–4.97) | 0.95 |
CRP, C-reactive protein; DBP, diastolic blood pressure; HDL, high-density lipoprotein cholesterol; SBP, systolic blood pressure.
Data are presented as mean (SD) unless otherwise specified.
aMedian (intra-quartile range).