Table 2.
Histological findings of the myocardium in native, I/R + vehicle and I/R + EP4RAG rats 7 days after operation
| TX group | Myocardial infiltration (counts) | Myocardial fibrosis (%) | Immunohistochemsity (0–5) |
|||||
|---|---|---|---|---|---|---|---|---|
| ED1 | CD4 | CD8 | MCP-1 | MMP-2 | MMP-9 | |||
| Vehicle (3 mg/kg) | 644 ± 71 | 26 ± 4.3 | 2.8 ± 0.7 | 3.1 ± 0.9 | 2.8 ± 1.2 | 3.0 ± 0.9 | 2.6 ± 0.6 | 2.5 ± 0.8 |
| EP4RAG (3 mg/kg) | 79 ± 15* | 6.9 ± 2.4 | 1.3 ± 0.5* | 1.4 ± 0.5* | 0.6 ± 0.4* | 1.2 ± 0.5* | 1.1 ± 0.6* | 0.7 ± 0.5* |
| Native | O ± O* | O ± O* | O ± O* | O ± O* | O ± O* | O ± O* | O ± O* | O ± O* |
Mean ± SEM pathological values were compared among the groups using Scheffe’s ANOVA.
*P < 0.05 compared with rat given vehicle.