Figure 2.
Time course of sphingosine kinase (SK) activity in pre- and postconditioning. (A) Schematic graphs showing the time course of SK activity in response to ischaemia and reperfusion in isolated hearts that had been subjected to ischaemic preconditioning or not. Compared with non-preconditioned hearts, preconditioned hearts had a smaller decline in SK activity and recovered to near normal levels during reperfusion. Adapted from data in Vessey et al.89 (B) Schematic graphs showing the time course of SK activity in response to ischaemia and reperfusion in isolated hearts that were subjected to ischaemic postconditioning or not. Non-postconditioned hearts exhibited a marked decline in SK activity during ischaemia, which did not recover during reperfusion. In contrast, postconditioned hearts, while displaying a similar reduction in SK activity during ischaemia, recovered substantially during reperfusion. Adapted from data in Jin et al.100