Table 1.
Roles for S1P2 receptor in development and disease of the cardiovascular system
| Model system | Function and pathophysiology |
|---|---|
| Miles-apart gene mutations (Zebrafish) | Cardiac defects (cardia bifida)85 |
| S1p1−/−S1p2−/− mice | Haemorrhage at E11.5, capillary network underdeveloped in mouse embryo87 |
| S1p2−/−S1p3−/− mice | Haemorrhage at E13.5, red blood cells and oedema in subcutaneous areas, endothelial cells with thin cell body87 |
| S1p1−/−S1p2−/−S1p3−/− mice | Haemorrhage at E10.5, vascular remodelling defects in the embryo head87 |
| S1p2−/− mice | Hearing loss, vascular remodelling defects in Stria vascularis structure of the inner ear87 |
| S1p2−/− mice | Increased regional blood flow, decreased vascular resistance99 |
| S1p2−/− mice | Enhanced revascularization of the hypoxic mouse retina97 |
| S1p2−/− mice | Increased neointimal lesions development in mouse artery102 |
| S1p2−/−S1p3−/− mice | Increased infarct size upon myocardial ischaemia–reperfusion injury100 |
| JTE-013 antagonist | Increased angiogenesis in Matrigel mouse implants96 |
| JTE-013 antagonist | Inhibition of H2O2-induced lung oedema73 |