TABLE 1.
SMD-Induced Changes in the Expression of Genes in the Category “Response to Oxidative Stress” from www.genesifter.net. Values Shown Are Means of Absolute Fluorescence Values (n = 3). Statistical Analysis Was Done by Genesifter Software Using an ANOVA with Benjamini-Hochberg Correction. The Dosage of SMD in milligrams/kilogram Body Weight Is Indicated in Parentheses. Values that Are Increased in Expression Are Indicated by Bold Print, and the Others Are Decreased
| Affymetrix ID | Gene Name | LPS | LPS + SMD (100) | LPS + SMD (200) | LPS + SMD (300) | p value |
| 1426875_s_at | Sulfiredoxin 1 homolog (Saccarhomyces cerevisiae) | 376.0 | 1454.5 | 2582.2 | 2583.3 | 0.002272 |
| 1451680_at | Sulfiredoxin 1 homolog (Saccarhomyces cerevisiae) | 127.7 | 350.6 | 719.1 | 618.6 | 0.001677 |
| 1422433_s_at | Isocitrate dehydrogenase 1 (NADP+), soluble | 781.9 | 1770.4 | 2760.1 | 6781.6 | 0.000479 |
| 1419821_s_at | Isocitrate dehydrogenase 1 (NADP+), soluble | 520.5 | 1271.0 | 1521.3 | 4139.4 | 0.000197 |
| 1418627_at | Glutamate-cysteine ligase, modifier subunit | 294.3 | 702.2 | 1313.0 | 968.8 | 0.002926 |
| 1429972_s_at | Thioredoxin reductase 2 | 61.6 | 143.8 | 130.9 | 210.9 | 0.028776 |
| 1416430_at | Catalase | 6100.5 | 8235.3 | 10584.0 | 12164.6 | 0.00019 |
| 1433866_x_at | Peroxiredoxin 1 | 8446.9 | 11910.1 | 14555.7 | 14674.3 | 0.003185 |
| 1417491_at | Cathepsin B | 1883.9 | 2446.8 | 3083.6 | 3312.7 | 0.006226 |
| 1460725_at | Xeroderma pigmentosum, complementation group A | 347.1 | 353.7 | 517.1 | 728.6 | 0.003233 |
| 1417492_at | Cathepsin B | 2634.8 | 3132.5 | 3655.1 | 4585.3 | 0.003054 |
| 1417694_at | Growth factor receptor bound protein 2–associated protein 1 | 1134.2 | 1733.4 | 1665.0 | 1376.6 | 0.034644 |
| 1416000_a_at | Peroxiredoxin 1 | 17857.0 | 21490.3 | 28237.0 | 24461.1 | 0.023674 |
| 1416429_a_at | Catalase | 4223.1 | 5524.8 | 4793.3 | 6584.7 | 0.016235 |
| 1426798_a_at | Protein phosphatase 1, regulatory (inhibitor) subunit 15b | 10400.8 | 13307.9 | 15165.4 | 12681.2 | 0.020064 |
| 1436691_x_at | Peroxiredoxin 1 | 20726.7 | 24007.5 | 28504.5 | 28376.3 | 0.041459 |
| 1417784_at | Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) | 49.8 | 17.4 | 81.9 | 106.8 | 0.018596 |
| 1454976_at | Superoxide dismutase 2, mitochondrial | 7040.7 | 8671.7 | 7479.4 | 3676.7 | 0.005291 |
| 1418333_at | Metal response element–binding transcription factor 1 | 377.2 | 398.2 | 283.2 | 259.4 | 0.013446 |
| 1428979_at | Metal response element–binding transcription factor 1 | 859.1 | 847.7 | 720.1 | 402.8 | 0.001567 |
| 1415676_a_at | Proteasome (prosome, macropain) subunit, beta type 5 | 3411.3 | 2939.0 | 2392.8 | 1720.0 | 0.041332 |
| 1449106_at | GSH peroxidase 3 | 384.5 | 320.3 | 214.5 | 188.6 | 0.031448 |
| 1416130_at | Prion protein | 242.1 | 179.7 | 110.8 | 122.0 | 0.028782 |
| 1431981_at | HIF-1, alpha subunit | 60.3 | 32.8 | 8.9 | 7.2 | 0.039661 |
Note. NADP: nicotinamide adenine dinucleotide phosphate.