Figure 1.

Sigmoidal dose–response curves for single dose against C. glabrata isolates A3 (CAS-S) (a, b and c), 05-62 (CAS-R1) (d, e and f) and 04-1748 (CAS-R2) (g and h) for single dose administration of aminocandin (a, d and g) and caspofungin (b, e and g), and daily doses of caspofungin (c and f). Symbols (closed circles) represent the means plus or minus the standard deviations of colony-forming units per gram of tissue, and the bars represent the corresponding median values. ED₅₀, dose resulting in 50% reduction in colony-forming units compared with controls.