Table 1.
Characteristics of 6,481 participants by loop diuretic use at the 4th examination
| Category of loop diuretic use | |||
|---|---|---|---|
| Variable | Nonuser n = 5827 |
User N = 654 |
P-value |
| Total hip BMD, g/cm2, mean (± SD) | 0.730 (0.131) | 0.728 (0.141) | .75 |
| Femoral neck BMD, g/cm2, mean (± SD) |
0.626 (0.114) | 0.628 (0.117) | .77 |
| Trochanter BMD, g/cm2, mean (± SD) |
0.551 (0.105) | 0.542 (0.110) | .14 |
| Age, y, mean (± SD) | 76.6 (4.8) | 79.4 (5.9) | < .001 |
| Alcoholic drinks consumed weekly, mean (± SD) |
1.4 (3.2) | 0.9 (2.9) | < .001 |
| Number of IADL impairments, mean (SD) |
0.6 (1.2) | 1.8 (1.7) | < .001 |
| Total daily calcium intake, mg, mean (± SD) |
1003 (790) | 861 (678) | <.001 |
| Total energy expended per week, kcal, mean (± SD) |
1279 (1454) | 646 (1115) | <.001 |
| Weight, kg, mean (± SD) | 65.3 (12.3) | 68.9 (15.1) | <.001 |
| Weight change v4 to 6, kg, mean (± SD) |
−1.09 (4.89) | −3.09 (6.66) | <.001 |
| Self-rated health, good/excellent vs. fair/poor/very poor (%) |
4703 (80.9) | 415 (63.7) | < .001 |
| Hypertension (%) | 1842 (31.7) | 423 (64.9) | <.001 |
| CHF (%) | 185 (3.2) | 212 (32.5) | <.001 |
| Chronic obstructive pulmonary disease (%) |
564 (9.7) | 128 (19.6) | <.001 |
| Diabetes (%) | 321 (5.5) | 95 (14.6) | <.001 |
| Current estrogen use (%) | 985 (16.9) | 99 (15.1) | .25 |
| Current cigarette smoker (%) | 380 (6.5) | 21 (3.2) | <.001 |
| Current statin use (%) | 207 (3.6) | 39 (6.0) | .002 |
| Current vitamin D supplement use (%) |
2258 (38.8) | 251 (38.4) | .85 |
| 2 or more falls in the past year (%) | 661 (11.4) | 107 (16.4) | <.001 |
BMD = bone mineral density
CHF = congestive heart failure
IADL = instrumental activities of daily living