Table 3.
Comparison of mean annualized % BMD change from baseline between continuous, intermittent, and non-loop diuretic users (n=2980)
| Loop diuretic group | |||||
|---|---|---|---|---|---|
| Nonuser (n=2622) |
Intermittent (n=197) |
Continuous (n=161) |
P(trend) | ||
| Total hip | Age-adjusted (95% CI) |
−0.70 (−0.75, −0.65) |
−0.98 (−1.16, −0.80) |
−0.90 (−1.10, −0.69) |
.004 |
| Multivariable adjusted (95% CI)† |
−0.71 (−0.76, −0.66) |
−0.93 (−1.11, −0.75) |
−0.79 (−1.00, −0.57) |
.12 | |
| Propensity score method (95% CI) |
−0.71 (−0.76, −0.66) |
−0.93 (−1.12, −0.74) |
−0.80 (−1.03, −0.56) |
.11 | |
| Femoral neck |
Age-adjusted (95% CI) |
−0.53 (−0.59, −0.47) |
−0.58 (−0.80, −0.36) |
−0.76 (−1.00, −0.51) |
.08 |
| Multivariable adjusted (95% CI)† |
−0.53 (−0.59, −0.47) |
−0.58 (−0.81, −0.36) |
−0.67 (−0.93, −0.40) |
.32 | |
| Propensity score method (95% CI) |
−0.53 (−0.59, −0.47) |
−0.57 (−0.80, −0.34) |
−0.68 (−0.95, −0.41) |
.31 | |
| Trochanter | Age-adjusted (95% CI) |
−0.66 (−0.72, −0.59) |
−0.93 (−1.16, −0.70) |
−0.78 (−1.04, −0.52) |
.08 |
| Multivariable adjusted (95% CI)† |
−0.66 (−0.73, −0.60) |
−0.88 (−1.12 −0.65) |
−0.70 (−0.98, −0.43) |
.33 | |
| Propensity score method (95% CI) |
−0.66 (−0.73, −0.60) |
−0.88 (−1.12 −0.64) |
−0.72 (−1.01, −0.43) |
.30 | |
†
Adjusted for age, baseline weight (kg), baseline site-specific BMD (g/cm2), functional status, alcohol use (drinks/week), total daily calcium intake (mg), physical activity (kcals burned per week), self reported health status, history of hypertension, history of CHF, change in weight (kg), history of diabetes mellitus type 2, smoking status, and use of statins. There were N=82 women who were not included in the multivariate models due to missing covariate data.