Table 2.
Age at the time of ICD implantation and long-term mortality
| Age at the time of ICD implantation (years) | Mortality |
Unadjusted models |
Multivariable-adjusted modelsa |
||||
|---|---|---|---|---|---|---|---|
| n | Events/100 person-years (no. of events) | Median survival in years | Hazard ratiob (95% CI) | P-value | Hazard ratiob (95% CI) | P-value | |
| <65 | 248 | 2.9 (31) | >12.4 | Reference group | — | Reference group | — |
| 65–75 | 135 | 7.1 (38) | 9.3 | 2.5 (1.5–4.0) | <0.001 | 2.8 (1.7–4.8) | <0.001 |
| >75 | 119 | 13.6 (50) | 5.3 | 4.7 (3.0–7.4) | <0.001 | 4.7 (2.8–7.9) | <0.001 |
CI, confidence interval.
aAdjusted for sex, prior sudden cardiac death, ICD implantation indication, history of congestive heart failure, left ventricular ejection fraction ≤35%, ischaemic cardiomyopathy diagnosis, prior coronary revascularization, renal disease, stroke, hypertension, dyslipidaemia, history of cigarette smoking, history of malignancy, diabetes mellitus, and chronic obstructive pulmonary disease.
bUsing Wald tests to assess the overall associations, age was strongly associated with total mortality in both unadjusted (P < 0.001) and adjusted models (P < 0.001).