Table 1.
Number of recorded reasons for disqualifications from KEEPS by screening examination(s)
| Number | |
|---|---|
| History | |
| Depression | 3 |
| Over age (>59 year) | 1 |
| LMP >3 year | 6 |
| Not menopausal | 19 |
| DES exposure in utero | 3 |
| Uterine ablation/hysterectomy | 6 |
| Cardiovascular disease | 2 |
| Medication or hormone use | 14 |
| Thromboembolic disease | 2 |
| History of cancer | 2 |
| HIV+ | 1 |
| Hypertension | 4 |
| Cerebrovascular disease | 1 |
| Gall bladder disease | 0 |
| Diabetes mellitus | 3 |
| Smoke >10 cig/day | 1 |
| Other history | 7 |
| Laboratory tests | |
| E2 >40 pg/mL | 62 |
| FSH <35 ng/mL | 24 |
| LDL >190 mg/dL | 30 |
| Trig >400 mg/dL | 2 |
| Hypothyroid (TSH >5 mL U/L) | 4 |
| Hyperthyroid (TSH <0.2, fT4 >2 mL U/L) | 3 |
| Other | 15 |
| Physical examination | |
| Hypertension (150/95) | 4 |
| BMI >35 mm2/kg | 11 |
| Breast mass | 3 |
| Abnormal cardiovascular exama | 2 |
| Abnormal pelvic exam | 5 |
| Other PE finding | 4 |
| Other screening tests | |
| CAC scan score >50 AU | 42 |
| CIMT scan abnormal | 0 |
| Transvaginal ultrasound >5 mm or abnormal | 31 |
| PAP smear abnormal | 4 |
| BDI score >17 (depressed) | 10 |
| MMSE score <23 (demented) | 0 |
| Mammogram abnormal | 6 |
| ECG abnormala | 12 |
| Endometrial aspirate abnormal | 4 |
| Other imaging/testing abnormal | 5 |
LMP last menstrual period, DES diethylstilbestrol, BMI body mass index, E2 17β-estradiol, FSH follicle-stimulating hormone, LDL low-density lipoprotein, Trig triglycerides, CAC coronary arterial calcium, AU Agatston units, CIMT carotid intima–media thickness, BDI Beck Depression Inventory, MMSE minimental state examination, ECG electrocardiogram
aEvidence of myocardial infarction, angina, or congestive heart failure