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Aryltetrazole and aryltriazole P2X7 antagonists
| Compound | hP2X7 pIC50 | rP2X7 pIC50 | |
|---|---|---|---|
| Tetrazoles | 6 | 6.9 | 6.5 |
| 40 | 7.8 | 7.2 | |
| 41 | 7.0 | 6.6 | |
| 42 | 7.9 | 7.3 | |
| Triazoles | 43 | 6.3 | 6.4 |
| 44 | 7.1 | 6.7 | |
| 45 | 7.7 | 7.1 | |
| 46 | 6.7 | 6.4 | |
| Aminotriazoles | 47 | 7.8 | 6.7 |
| 48 | 7.3 | 6.5 | |
| 49 | 7.7 | 7.4 | |
| 50 | 8.0 | 7.6 | |
| 51 | 7.6 | 6.7 | |
| 52 | 7.8 | 6.9 | |
| 53 | 7.9 | 6.9 | |
| 54 | 7.8 | 6.6 | |
| 55 | 5.8 | 5.6 | |
| 56 | 7.8 | 7.9 | |
| 57 | 7.5 | 7.5 |
